Verruculogen

CAT: 0804-HY-N6688-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N6688-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca2+-activated K+ currents. Verruculogen induces severe tremors in infected animals[1][2][3][4][5].
CAS Number
[12771-72-1]
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Bacterial; Potassium Channel
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/verruculogen.html
Purity
98.08
Solubility
DMSO : ≥ 50 mg/mL
Smiles
C/C(C)=C\[C@@H]1N2C3=C([C@@H]([C@@]4(N(C([C@@]5([H])N(CCC5)C4=O)=O)[C@@]3([H])CC(C)(OO1)C)O)O)C6=CC=C(OC)C=C62
Molecular Formula
C27H33N3O7
Molecular Weight
511.57
Precautions
H301, H311, H331
References & Citations
[1]Luciane M. Kawashima, et al. The development of an analytical method for two mycotoxins, patulin and verruculogen, and survey of their presence in commercial tomato pulp. Brazilian Journal of Microbiology|[2]Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33 (19) :5819-28.|[3]Cui CB, et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo) . 1996 Jun;49 (6) :534-40.|[4]Huang MH, et al. Stimulatory actions of thymol, a natural product, on Ca (2+) -activated K (+) current in pituitary GH (3) cells. Planta Med. 2005 Dec;71 (12) :1093-8. |[5]Intorre L, et al. Behavioural and biochemical effects of the Tremorgenic Mycotoxin Verruculogen. Toxicological & Environmental Chemistry, 1994, 46 (1-2) : 119-125.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName

Alternative Products

CatalogName
sc-204939AVerruculogen
MSS1037-01Pribolab® Verruculogen
BIV1002-01Verruculogen from Penicillium verruculosum
226788Verruculogen (NA 209A, TR 1)

Popular Products