Verruculogen

• Description :

  Verruculogen is a tremorgenic mycotoxin and inhibitor of the M phase of the mammalian cell cycle. Verruculogen is produced by Penicillium and Aspergillus species. Verruculogen enhances the binding of ChTX to maxi-k channels with a K1/2 value of 170 nM. Verruculogen inhibits the amplitude of Ca2+-activated K+ currents. Verruculogen induces severe tremors in infected animals[1][2][3][4][5].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331

• Target :

  Bacterial; Potassium Channel

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/verruculogen.html

• Purity :

  98.08

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  C/C(C)=C\[C@@H]1N2C3=C([C@@H]([C@@]4(N(C([C@@]5([H])N(CCC5)C4=O)=O)[C@@]3([H])CC(C)(OO1)C)O)O)C6=CC=C(OC)C=C62

• Molecular Formula :

  C27H33N3O7

• Molecular Weight :

  511.57

• Precautions :

  H301, H311, H331

• References & Citations :

  [1]Luciane M. Kawashima, et al. The development of an analytical method for two mycotoxins, patulin and verruculogen, and survey of their presence in commercial tomato pulp. Brazilian Journal of Microbiology|[2]Knaus HG, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33 (19) :5819-28.|[3]Cui CB, et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo) . 1996 Jun;49 (6) :534-40.|[4]Huang MH, et al. Stimulatory actions of thymol, a natural product, on Ca (2+) -activated K (+) current in pituitary GH (3) cells. Planta Med. 2005 Dec;71 (12) :1093-8. |[5]Intorre L, et al. Behavioural and biochemical effects of the Tremorgenic Mycotoxin Verruculogen. Toxicological & Environmental Chemistry, 1994, 46 (1-2) : 119-125.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [12771-72-1]