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NSC624206

CAT: 0804-HY-103436-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103436-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC624206 is an inhibitor of ubiquitin E1 (UBA1), with an IC50 of ~9 μM. NSC624206 specifically blocks ubiquitin-thioester formation (IC50=13 μM) but has no effect on ubiquitin adenylation[1].
CAS Number
13116-77-3
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nsc624206.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCCCCCCCNCCSSCC1=CC=C(Cl)C=C1.[H]Cl
Molecular Formula
C19H33Cl2NS2
Molecular Weight
410.51
References & Citations
[1]Dana Ungermannova, et al. Identification and Mechanistic Studies of a Novel Ubiquitin E1 Inhibitor. J Biomol Screen . 2012 Apr;17 (4) :421-34.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T12265-01NSC624206

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