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Neptinib

CAT: 0804-HY-164503-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164503-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Neptinib (NEP010) is an orally active derivative of Afatinib that has stronger antitumor activity than Afatinib (HY-10261) by improving pharmacokinetics. Neptinib has a significant inhibitory effect on tumor growth in mouse non-small cell lung cancer models with different EGFR mutations. Neptinib has a certain inhibitory effect on the EGFR kinase family, with IC50 values of 0.24 nM, 7.25 nM, 0.46 nM and 1.79 nM for EGFRwt, EGFRL858R/T790M, EGFRL858R and EGFRT790M, respectively[1].
CAS Number
2085843-51-0
Product Name Alternative
NEP010
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/neptinib.html
Smiles
FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(OCC)=C3
Molecular Formula
C22H23ClFN5O2
Molecular Weight
443.90
References & Citations
[1]Yidong Feng, et al. "NEP010, a novel compound with minor structural modification from afatinib, exhibited significantly improved antitumor activity." European Journal of Pharmacology 946 (2023) : 175620.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

Alternative Products

CatalogName
T89923-01Neptinib
AR-N01305-01Neptinib-d5

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