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P7C3-A20

CAT: 0804-HY-15978-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15978-01Size:5 mg
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Description
P7C3-A20 is a derivative of P7C3 with potent proneurogenic and neuroprotective activity. P7C3-A20 exerts an antidepressant-like effect. P7C3-A20 can cross the blood-brain barrier and therefore has the potential for brain injury treatment[1][2][3].
CAS Number
1235481-90-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/P7C3-A20.html
Concentration
10mM
Purity
98.79
Solubility
DMSO : ≥ 100 mg/mL
Smiles
FC(CNC1=CC(OC)=CC=C1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24
Molecular Formula
C22H19Br2FN2O
Molecular Weight
506.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Blaya MO et al. Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury. J Neurotrauma. 2014 Mar 1;31 (5) :476-86.|[2]Walker AK et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasinghippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20 (4) :500-8.|[3]Junjie Bai, et al. The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic-Ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling. Neuroscience. 2020 Jun 3; S0306-4522 (20) 30353-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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