Products for Research Use Only
RegisterLogin

Lifitegrast-d4-1

CAT: 0804-HY-19344S2Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-19344S2Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Lifitegrast-d4-1 is deuterium labeled Lifitegrast. Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease[1][2].
UNSPSC
12352005
Target
Integrin; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Cytoskeleton; Others
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@H](C(O)=O)CC1=CC=CC(S(C)(=O)=O)=C1)C2=C(Cl)C3=C(C([2H])([2H])N(C(C4=CC=C5C=COC5=C4)=O)C([2H])([2H])C3)C=C2Cl
Molecular Formula
C29H20D4Cl2N2O7S
Molecular Weight
619.51
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Perez VL, et al. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 Apr;14 (2) :207-15.|[3]Sun Y, et al. Corneal inflammation is inhibited by the LFA-1 antagonist, lifitegrast (SAR 1118) . J Ocul Pharmacol Ther. 2013 May;29 (4) :395-402.|[4]Rao VR, et al. Delivery of SAR 1118 to the retina via ophthalmic drops and its effectiveness in a rat streptozotocin (STZ) model of diabetic retinopathy (DR) . Invest Ophthalmol Vis Sci. 2010 Oct;51 (10) :5198-204.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-19344SLifitegrast-d4
HY-19344-01Lifitegrast
HY-19344A-01Lifitegrast (sodium)
HY-19344S1Lifitegrast-d6
HY-19344R-01Lifitegrast (Standard)
HY-23529-01Lifitegrast impurity 6
HY-Z0791-01Lifitegrast impurity 4 (hydrochloride)
HY-23529RLifitegrast impurity 6 (Standard)
HY-Z0791RLifitegrast impurity 4 (hydrochloride) (Standard)
HY-W011591S21-Bromotetradecane-d4

Alternative Products

CatalogName
TRC-L465957-75MGLifitegrast-d4
AR-L07262-01Rac-Lifitegrast-d4
RM-L090601-01Lifitegrast Impurity 1
BA4581-10Lifitegrast

Popular Products