Cedrol

CAT: 0804-HY-N2071-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2071-01Size:100 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Cedrol is a potent competitive inhibitor of cytochrome P-450 (CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties[1][2][3][4][5][6][7].
CAS Number
[77-53-2]
Product Name Alternative
(+) -Cedrol; α-Cedrol
UNSPSC
12352211
Hazard Statement
H315, H319, H320
Target
Apoptosis; Caspase; Cytochrome P450; Fungal; Platelet-activating Factor Receptor (PAFR)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cedrol.html
Purity
99.76
Solubility
DMSO : 110 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O[C@@]1(CC[C@]23[C@@H](CC[C@]2(C(C)([C@]1(C3)[H])C)[H])C)C
Molecular Formula
C15H26O
Molecular Weight
222.37
Precautions
H315, H319, H320
References & Citations
[1]Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77 (22-24) :1522-32.|[2]Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24 (1) :16-21|[3]Özek G, et al. Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species. Molecules. 2021 Dec 16;26 (24) :7644. |[4]Chien JH, et al. Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death. Int J Med Sci. 2022 Oct 31;19 (13) :1953-1964.|[5]Zhang K, et al. Anxiolytic Effect of Cedrol on Behavior and Brain Neurotransmitter Levels of Female Mice. Biol Pharm Bull. 2019 Sep 1;42 (9) :1575-1580.|[6]Chen SS, et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ Toxicol Pharmacol. 2016 Sep;46:270-276. |[7]Sakhaee MH, et al. Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation. Metab Brain Dis. 2020 Oct;35 (7) :1119-1126.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
CYP2; CYP3

Related Products

CatalogName
HY-W009417-01Cedryl acetate
HY-W009417R-01Cedryl acetate (Standard)
HY-W013401-01Methyl Cedryl Ketone
HY-N3562Cedrin
HY-W1121877Cedrenol

Alternative Products

CatalogName
C6943-100Cedrol
BIA0126-01(+) -Cedrol
TRC-C228820-1G(+)-Cedrol
C05950-01Cedrol 99%
TBI4405-250MGCedrol (+), Anticancer natural product
MBS1398889Recombinant Artemisia annua Epi-cedrol synthase (ECS1), partial

Popular Products