Cedrol

• Description:

  Cedrol is a potent competitive inhibitor of cytochrome P-450 (CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties[1][2][3][4][5][6][7].

• Product Name Alternative:

  (+) -Cedrol; α-Cedrol

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H320

• Target:

  Apoptosis; Caspase; Cytochrome P450; Fungal; Platelet-activating Factor Receptor (PAFR)

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/cedrol.html

• Purity:

  99.76

• Solubility:

  DMSO : 110 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles:

  O[C@@]1(CC[C@]23[C@@H](CC[C@]2(C(C)([C@]1(C3)[H])C)[H])C)C

• Molecular Formula:

  C15H26O

• Molecular Weight:

  222.37

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77 (22-24) :1522-32.|[2]Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24 (1) :16-21|[3]Özek G, et al. Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species. Molecules. 2021 Dec 16;26 (24) :7644. |[4]Chien JH, et al. Cedrol restricts the growth of colorectal cancer in vitro and in vivo by inducing cell cycle arrest and caspase-dependent apoptotic cell death. Int J Med Sci. 2022 Oct 31;19 (13) :1953-1964.|[5]Zhang K, et al. Anxiolytic Effect of Cedrol on Behavior and Brain Neurotransmitter Levels of Female Mice. Biol Pharm Bull. 2019 Sep 1;42 (9) :1575-1580.|[6]Chen SS, et al. Preventive effects of cedrol against alopecia in cyclophosphamide-treated mice. Environ Toxicol Pharmacol. 2016 Sep;46:270-276. |[7]Sakhaee MH, et al. Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation. Metab Brain Dis. 2020 Oct;35 (7) :1119-1126.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  CYP2; CYP3

• CAS Number:

  [77-53-2]