Eritoran (tetrasodium)

Eritoran (tetrasodium)

• CAS Number: 185954-98-7
• UNSPSC Description: Eritoran tetrasodium (E5564) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity[1][2].
• Target Antigen: EBV; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Anti-infection;Immunology/Inflammation
• Applications: COVID-19-anti-virus
• Field of Research: Infection; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/eritoran-tetrasodium.html
• Solubility: 10 mM in DMSO
• Smiles: CCCCCCC[C@@H](OC)CCO[C@@H]1[C@H]([C@@H](O[C@H](COC)[C@H]1OP(O[Na])(O[Na])=O)OC[C@@H]2[C@H]([C@@H]([C@@H](NC(CC(CCCCCCCCCCC)=O)=O)[C@@H](OP(O[Na])(O[Na])=O)O2)OCCCCCCCCCC)O)NC(CCCCCCCCC/C=C\CCCCCC)=O
• Molecular Weight: 1401.58
• References & Citations: [1]Younan P, et al. The Toll-Like Receptor 4 Antagonist Eritoran Protects Mice from Lethal Filovirus Challenge. mBio. 2017 Apr 25;8(2):e00226-17|[2]Sun Y, et al. Inhibition of corneal inflammation by the TLR4 antagonist Eritoran tetrasodium (E5564). Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1247-54.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 3