Oryzalin

• Description :

  Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H350, H360, H411

• Target :

  Herbicide; Microtubule/Tubulin

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/oryzalin.html

• Concentration :

  10mM

• Purity :

  99.62

• Solubility :

  DMSO : 233.33 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=CC([N+]([O-])=O)=C(N(CCC)CCC)C([N+]([O-])=O)=C1)(N)=O

• Molecular Formula :

  C12H18N4O6S

• Molecular Weight :

  346.36

• Precautions :

  H350, H360, H411

• References & Citations :

  [1]Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172 (2) :252-64.|[2]Bouvier L, et al. Oryzalin as an efficient agent for chromosome doubling of haploid apple shoots in vitro. Plant Breeding, 1994, 113 (4) : 343-346.|[3]Lopes RM, et al. Formulation of oryzalin (ORZ) liposomes: in vitro studies and in vivo fate. Eur J Pharm Biopharm. 2012 Oct;82 (2) :281-90.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [19044-88-3]