Ifenprodil

• Product Name Alternative:

  RC 61-91; NP-120

• UNSPSC Description:

  Ifenprodil (RC 61-91) is a noncompetitive NMDA receptor antagonist with anti-excitotoxic activity. Ifenprodil significantly improves long-term sensorimotor and spatial learning deficits in mice after acute subarachnoid hemorrhage. Ifenprodil reduces neuronal cell death in the basal cortex and CA1 region of the hippocampus induced by experimental subarachnoid hemorrhage. Ifenprodil attenuates Ca2+ overload in basal cortical cells and mitochondria, as well as brain edema in blood-brain barrier damage and early brain injury. Ifenprodil reduces the intracellular Ca2+ increase and apoptosis of primary cortical neurons under conditions of high glutamate concentrations. Ifenprodil also reduces the increase in endothelial permeability caused by high glutamate concentrations in human brain microvascular endothelial cells. Ifenprodil also inhibits GIRK channels and interacts with α1-adrenergic, 5-HT, and σ receptors[1].

• Target Antigen:

  iGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ifenprodil.html

• Smiles:

  OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3

• Molecular Weight:

  325.44

• References & Citations:

  [1]Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid HemorrhageChemosphere. 2019 Aug;229:618-630. |Heliyon. 2023 May 29, e16631.|Life Sci. 2022 Feb 17;295:120419.|Neurosci Bull. 2020 Feb;36(2):153-164. |Antimicrob Agents Chemother. 2024 Oct 3:e0103524.|Chemosphere. 2019 Aug;229:618-630. |Eur J Pharmacol. 2023 Nov 6:176174.|Eur J Pharmacol. 2024 Jul 25:176860.|Exp Brain Res. 2023 Oct 16.|Pharmaceuticals (Basel). 2024 Sep 19;17(9):1234.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  23210-56-2