(-) -Gallopamil

CAT: 0804-HY-118202Size: 1 EachDry Ice: NoHazardous: No

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Description

(-) -Gallopamil exerts a selective modulation of the fast voltage-dependent inactivation. (-) -Gallopamil inhibits efficiently Cav1.2 constructs formed by β-subunits (promoting fast voltage-dependent inactivation) . (-) -Gallopamil also accelerates the voltage-dependent phase of ICa decay (as well as the voltage-dependent decay of Ba2+ currents) . (-) -Gallopamil is promising for research of antiarrhythmics[1][2].

CAS Number

36622-40-9

Product Name Alternative

(-) -Methoxyverapamil

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/minus-gallopamil.html

Smiles

N#C[C@](CCCN(C)CCC1=CC=C(C(OC)=C1)OC)(C2=CC(OC)=C(C(OC)=C2)OC)C(C)C

Molecular Formula

C28H40N2O5

Molecular Weight

484.63

References & Citations

[1]Sokolov S, et al. On the role of Ca (2+) - and voltage-dependent inactivation in Ca (v) 1.2 sensitivity for the phenylalkylamine (-) gallopamil. Circ Res. 2001 Oct 12;89 (8) :700-8. |[2]Sokolov S, et al. Inactivation determinant in the I-II loop of the Ca2+ channel alpha1-subunit and beta-subunit interaction affect sensitivity for the phenylalkylamine (-) gallopamil. J Physiol. 1999 Sep 1;519 Pt 2 (Pt 2) :315-22.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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(-) -Gallopamil

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