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VUF14862

CAT: 0804-HY-126748Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-126748Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling[1].
CAS Number
2223023-78-5
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vuf14862.html
Smiles
O=C(C1=CC=CC(/N=N/C2=CC=C(O[C@H]3C[C@H](N4CCCCC4)C3)C=C2)=C1)N5CCCC5
Molecular Formula
C26H32N4O2
Molecular Weight
432.56
References & Citations
[1]Hauwert NJ, et al. Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology. J Am Chem Soc. 2018 Mar 28;140 (12) :4232-4243.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19210240-01VUF14862

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