Products for Research Use Only
RegisterLogin

Recoflavone

CAT: 0804-HY-106449-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-106449-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Recoflavone (DA-6034 (free acid) ), a synthetic derivative of the flavonoid Eupatilin , is orally active. Recoflavone can inhibit the NF-κB pathway and induce [Ca (2+) ]i increase in epithelial cells. Recoflavone exhibits activities such as anti-inflammation, anti-tumor effects, protection of gastric and intestinal mucosa, and promotion of secretion in the ocular surface and salivary glands. Recoflavone can be used for the research of diseases such as dry eye, gastric injury, and intestinal injury[1][2][3][4].
CAS Number
203191-10-0
Product Name Alternative
DA-6034 (free acid)
UNSPSC
12352005
Target
Apoptosis; Calcium Channel; COX; ERK; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/recoflavone.html
Purity
98.0
Solubility
DMSO : 40 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
COC1=C2C(OC(C3=CC(OC)=C(OC)C=C3)=CC2=O)=CC(OCC(O)=O)=C1
Molecular Formula
C20H18O8
Molecular Weight
386.35
References & Citations
[1]Choi SM, et al. Effects of DA-6034, a flavonoid derivative, on mucin-like glycoprotein and ocular surface integrity in a rabbit model. Arzneimittelforschung. 2009;59 (10) :498-503. ; Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10 (3) :406-411. |[2]Kwak DS, Lee OY, Lee KN, et al. The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model. Gut Liver. 2016;10 (3) :406-411. ; Kim YW, Lee WH, Choi SM, et al. DA6034 promotes gastric epithelial cell migration and wound-healing through the mTOR pathway. J Gastroenterol Hepatol. 2012;27 (2) :397-405. |[3]Nam SY, et al. DA-6034, a derivative of flavonoid, prevents and ameliorates dextran sulfate sodium-induced colitis and inhibits colon carcinogenesis. Exp Biol Med (Maywood) . 2008;233 (2) :180-191.|[4]Yang YM, et al. DA-6034 Induces [Ca (2+) ]i Increase in Epithelial Cells. Korean J Physiol Pharmacol. 2014 Apr;18 (2) :89-94.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

Alternative Products

CatalogName
TRC-R142020-25MGRecoflavone

Popular Products