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DICER1

CAT: 0579-X2771BSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0579-X2771BSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This peptide is the immunogen used to make Cat # X2756P. _x000B__x000B_Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. Blocking Peptide to Cat # X2756P.
Synonyms
Endoribonuclease Dicer, DICER, HERNA
Type
Blocking Peptide
Applications
Blocking Peptide
Assay Principle
Optimal concentration should be evaluated by serial dilutions.
Stability
See expiration date on vial
Concentration
See vial for Concentration
Form
Provided as solution in phosphate buffered saline with 0,08% sodium azide
Precautions
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.
Shipping Conditions
Ambient Temperature, freeze upon arrival
Storage Conditions
Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles
Functional Analysis
Neutralizing

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