Anti-Thyroglobulin Antibody

• Description:

  Mouse Monoclonal Antibody specific to Thyroglobulin

• Product Name Alternative:

  Tg

• Gene Name:

  TG

• NCBI Gene ID:

  TG

• UniProt:

  P01266

• Cellular Locus:

  Secreted

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Purified human thyroglobulin

• Target Antigen:

  Thyroglobulin

• Target:

  Thyroglobulin

• Clonality:

  Monoclonal

• Isotype:

  IgG1

• Type:

  Antibody

• Applications:

  ELISA

• Field of Research:

  Hormones/Proteins

• Purification Method:

  PEG Purified

• Concentration:

  Lot Specific

• Dilution:

  Dilute in PBS or medium which is identical to that used in the assay system.

• Format:

  Purified

• Form:

  Liquid

• Buffer:

  Phosphate Buffered Saline

• Function:

  Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:32025030, PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030). {PubMed:17532758, PubMed:32025030}.

• Additionnal Information:

  These antibodies may be used in ELISA to detect and quantitate thyroglobulin.

• Storage Conditions:

  These antibodies are stable for at least one (1) year at -20ºC to -70ºC. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

• Specificity:

  Thyroglobulin

• Formulation:

  PBS, pH 7.4.

• Buffer pH:

  pH 7.4

• CAS Number:

  9007-83-4