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Iluzanebart

CAT: 0804-HY-P990043-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P990043-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2) . Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP) [1].
CAS Number
2733621-19-5
Product Name Alternative
VGL101
UNSPSC
12352203
Target
Ser/Thr Kinase; TREM receptor
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/iluzanebart.html
Purity
98.63
Solubility
10 mM in DMSO
Smiles
[Iluzanebart]
Molecular Weight
(144.92 kDa)
References & Citations
[1]Larson KC, et al., Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. J Neuroinflammation. 2025 Jan 31;22 (1) :26.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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