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Fiacitabine

CAT: 0804-HY-50735-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-50735-01Size:1 mg
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Description
Fiacitabine (NSC 382097; FIAC; FOAC) is a selective inhibitior of DNA replication of herpes simplex virus (HSV) with IC50 values of 2.5 nM and 12.6 nM for HSV1 and HSV2, respectively. IC50 value: 2.5/12.6 nM (HSV1/2) [2] Target: HSV FIAC suppressed by 90% the replication of various strains of herpes simplex virus types 1 and 2 at concentrations of 0.0025 to 0.0126 microM. Cytotoxicity was minimal, as determined by trypan blue dye exclusion with norman Vero, WI-38, and NC-37 cell proliferation; the 50% inhibitory dose was 4 to 10 microM in a 4-day assay. FIAC was active at much lower concentrations than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine. It was slightly more active against herpes simplex virus type 1 than acycloquanosine and slightly more toxic to normal cells. FIAC was about 8,000 times more active against the replication of wild-type herpes simplex virus type 1 than against a mutant strain lacking the expression of virus-specified thymidine kinase [2].
CAS Number
69123-90-6
Product Name Alternative
NSC 382097; FIAC; FOAC
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
HSV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Fiacitabine.html
Concentration
10mM
Purity
99.27
Solubility
DMSO : 37 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@H](F)[C@H](N(C=C2I)C(N=C2N)=O)O1
Molecular Formula
C9H11FIN3O4
Molecular Weight
371.10
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Allaudeen HS, et al. Selective inhibition of DNA replication in herpes simplex virus infected cells by 1- (2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl) -5-iodocytosine. J Biol Chem. 1982 Oct 25;257 (20) :11879-82.|[2]Lopez C, et al. 2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent. Antimicrob Agents Chemother. 1980 May;17 (5) :803-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
HSV-1; HSV-2

Alternative Products

CatalogName
BA1999-1Fiacitabine
A11422-500Fiacitabine 500mg
A11422-25Fiacitabine 25mg
A11422-5Fiacitabine 5mg
A11422-50Fiacitabine 50mg
A11422-10Fiacitabine 10mg
A11422-100Fiacitabine 100mg
A11422-1Fiacitabine 1mg
A11422-10mM-DFiacitabine 10mM * 1mL in DMSO

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