Chimmitecan

• Description:

  Chimmitecan ((S) -9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].

• Product Name Alternative:

  (S) -9-Allyl-10-Hydroxycamptothecin

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/chimmitecan.html

• Purity:

  98.96

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C1[C@] (CC) (C2=C (C (N3CC4=CC5=C (C (O) =CC=C5N=C4C3=C2) CC=C) =O) CO1) O

• Molecular Formula:

  C23H20N2O5

• Molecular Weight:

  404.42

• Precautions:

  H301

• References & Citations:

  [1]Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13 (4) :1298-307.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  185425-25-6