Chimmitecan

• Description :

  Chimmitecan ((S) -9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity[1].

• CAS Number :

  [185425-25-6]

• Product Name Alternative :

  (S) -9-Allyl-10-Hydroxycamptothecin

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Topoisomerase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/chimmitecan.html

• Purity :

  98.96

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1[C@](CC)(C2=C(C(N3CC4=CC5=C(C(O)=CC=C5N=C4C3=C2)CC=C)=O)CO1)O

• Molecular Formula :

  C23H20N2O5

• Molecular Weight :

  404.42

• Precautions :

  H301

• References & Citations :

  [1]Huang M, et, al. Chimmitecan, a novel 9-substituted camptothecin, with improved anticancer pharmacologic profiles in vitro and in vivo. Clin Cancer Res. 2007 Feb 15;13 (4) :1298-307.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported