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Itolizumab

CAT: 0804-HY-P99252-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99252-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a humanized recombinant anti-CD6 monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19[1][2][3].
CAS Number
1116433-11-4
Product Name Alternative
Anti-Human CD6 Recombinant Antibody
UNSPSC
12352203
Target
CD6
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/itolizumab.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[Itolizumab]
Molecular Weight
(146.66 kDa)
References & Citations
[1]Saavedra D, et al. An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients. Immun Ageing. 2020 Nov 14;17 (1) :34. |[2]Loganathan S, et al. Itolizumab, an anti-CD6 monoclonal antibody, as a potential treatment for COVID-19 complications. Expert Opin Biol Ther. 2020 Sep;20 (9) :1025-1031. |[3]Srivastava A. Itolizumab in Psoriasis. Indian J Dermatol. 2017 Jul-Aug;62 (4) :418-421. |[4]Freitas RF, et al. Modulation of CD4 T cell function via CD6-targeting. EBioMedicine. 2019 Sep;47:427-435. |[5]Globig AM, et al. High-dimensional profiling reveals Tc17 cell enrichment in active Crohn's disease and identifies a potentially targetable signature. Nat Commun. 2022 Jun 27;13 (1) :3688. |[6]Bughani U, et al. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab. PLoS One. 2017 Jul 3;12 (7) :e0180088. |[7]Cherie Tracy Ng, et al. Itolizumab As a Potential Therapeutic for the Prevention and Treatment of Graft Vs Host Disease. Blood (2019) 134 (Supplement_1) : 5603.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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