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Nefiracetam

CAT: 0804-HY-B0340-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0340-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nefiracetam is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research[1][2][3][4][5][6].
CAS Number
77191-36-7
Product Name Alternative
DM9384; DZL-221
UNSPSC
12352005
Hazard Statement
H302
Target
Calcium Channel; GABA Receptor; iGluR; mGluR; nAChR; PKC
Type
Reference compound
Related Pathways
Epigenetics; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nefiracetam.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL|H2O : ≥ 25 mg/mL
Smiles
O=C(NC1=C(C)C=CC=C1C)CN2C(CCC2)=O
Molecular Formula
C14H18N2O2
Molecular Weight
246.30
Precautions
H302
References & Citations
[1]Nomura T, et al. Nefiracetam facilitates hippocampal neurotransmission by a mechanism independent of the piracetam and aniracetam action. Brain Res. 2000 Jul 7;870 (1-2) :157-62.|[2]Moriguchi S, et al. Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. J Neurochem. 2009 Jul;110 (1) :170-81.|[3]Nishizaki T, et al. A 'long-term-potentiation-like' facilitation of hippocampal synaptic transmission induced by the nootropic nefiracetam. Brain Res. 1999 May 1;826 (2) :281-8.|[4]Fukatsu T, et al. Effects of nefiracetam on spatial memory function and acetylcholine and GABA metabolism in microsphere-embolized rats. Eur J Pharmacol. 2002 Oct 18;453 (1) :59-67.|[5]Shiotani T, et al. Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benzodiazepine receptors. Brain Res. 2000 Mar 24;859 (2) :255-61.|[6]Yoshii M, et al. Cellular mechanisms underlying cognition-enhancing actions of nefiracetam (DM-9384) . Behav Brain Res. 1997 Feb;83 (1-2) :185-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
L-type calcium channel; mGluR5; NMDA Receptor; N-type calcium channel

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CatalogName
B1532-5.1Nefiracetam

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