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GB1107

CAT: 0804-HY-114409-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114409-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model[1].
CAS Number
1978336-61-6
Product Name Alternative
BE-34776
UNSPSC
12352005
Target
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/GB1107.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@H]([C@@H](N1N=NC(C2=CC(F)=C(F)C(F)=C2)=C1)[C@H]([C@@H](CO)O3)O)[C@H]3SC4=CC=C(Cl)C(Cl)=C4
Molecular Formula
C20H16Cl2F3N3O4S
Molecular Weight
522.32
References & Citations
[1]Vuong L, et al. An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade. Cancer Res. 2019 Jan 23. pii: canres.2244.2018.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Galectin-3

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A18591-100GB1107 100mg
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