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MK181

CAT: 0804-HY-122177Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122177Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK181 is an aldose reductase (AR) inhibitor with IC50s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10[1].
CAS Number
314297-32-0
UNSPSC
12352005
Target
Aldose Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mk181.html
Smiles
O=C(COC1=CC(Cl)=CC=C1C(NCC2=CC=C(C=C2)Br)=O)O
Molecular Formula
C16H13BrClNO4
Molecular Weight
398.64
References & Citations
[1]Alexandra Cousido-Siah, et al. IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors. ACS Chem Biol. 2016 Oct 21;11 (10) :2693-2705.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T28054-01MK181

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