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A-65317

CAT: 0804-HY-129607Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129607Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response[1][2].
CAS Number
122224-84-4
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a-65317.html
Smiles
O=C([C@@H](CC1=CNC=N1)NC([C@@H](CC(N(CCOCOCCOC)C)=O)CC2=CC=CC=C2)=O)N[C@H](C(O)[C@@H]3CN(C(O3)=O)CC)CC4CCCCC4
Molecular Formula
C38H58N6O9
Molecular Weight
742.90
References & Citations
[1]K M Verburg, et al. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259 (1 Pt 2) :R7-14.|[2]Saul H. Rosenberg, et al. Renin Inhibitors. Integration of Pharmaceutical Discovery and Development Chapter pp 7-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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