T-1101

CAT: 0804-HY-120356Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120356Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
T-1101 (TAI-95) is an orally active inhibitor for mitose regulating highly expressed oncoprotein 1 (Hec1) . T-1101 blocks the interaction between Hec1 and NEK2, exhibits cytotoxicity in human liver cancer cells with GI50 of 15-70 nM. T-1101 induces apoptosis in Huh-7. T-1101 exhibits antitumor efficacy in mouse models[1].
CAS Number
[1438638-83-5]
Product Name Alternative
TAI-95
UNSPSC
12352005
Target
Apoptosis; NEKs
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/t-1101.html
Smiles
O=C(C1=CC=NC=C1)NC2=NC(C3=C(C)C=C(SC4=NC=C(OCCOC)N=C4)C=C3C)=CS2
Molecular Formula
C24H23N5O3S2
Molecular Weight
493.60
References & Citations
[1]Huang LY, et al., Inhibition of Hec1 as a novel approach for treatment of primary liver cancer. Cancer Chemother Pharmacol. 2014 Sep;74 (3) :511-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
NEK2

Related Products

CatalogName
HY-113714C562-1101
HY-P991339ZL-1101
HY-W015764-01T-1105
HY-P77783-01HLA-A*1101 KRAS G12D, Human (HEK293, His-Avi)
HY-P705351-01HLA-A*1101 B2M Monomer, Human (Biotinylated, HEK293, His-Avi)
HY-P77786-01HLA-A*1101 KRAS G12V Complex, Human (HEK293, His-Avi)
HY-P700933HLA-A*1101 LMP2 Complex, Human (SSCSSCPLTK, HEK293, His-Avi)
HY-P77785HLA-A*1101 KRAS G12D Tetramer, Human (HEK293, His-Avi)
HY-P700922HLA-A*1101 KRAS G12C Complex, Human (VVVGACGVGK, HEK293, His-Avi)
HY-P705355-01HLA-A*1101 EGFR Complex, Human (Biotinylated, KITDFGRAK, HEK293, His-Avi)

Alternative Products

CatalogName
E2402-5mgT-1101 tosylate
530101ID-1101
MF-0100727-01ZL-1101
MF-0044189-01C562-1101
MBS5781468FT-1101
MBS5776414AV-1101
BFT-1101Analytical Balance (BFT-1101)
BFJ-1101Mini-PCR (BFJ-1101)
MBS5812752FT-1101 free base
2613-5CAL-101 (GS-1101)

Popular Products