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4′-Hydroxywogonin

CAT: 0804-HY-N1904-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N1904-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis[1][2][3].
CAS Number
57096-02-3
Product Name Alternative
8-Methoxyapigenin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; Bcl-2 Family; Caspase; IKK; Interleukin Related; NF-κB; p38 MAPK; PI3K; Reactive Oxygen Species (ROS) ; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxywogonin.html
Purity
98.22
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C2=CC=C(O)C=C2)OC3=C(OC)C(O)=CC(O)=C13
Molecular Formula
C16H12O6
Molecular Weight
300.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Fan C, et, al. 4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One. 2017 Aug 8;12 (8) :e0181191.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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