N3-Ph-NHS ester

• Description :

  N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H319, H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/n3-ph-nhs-ester.html

• Purity :

  99.88

• Solubility :

  DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(ON1C(CCC1=O)=O)C2=CC=C(N=[N+]=[N-])C=C2

• Molecular Formula :

  C11H8N4O4

• Molecular Weight :

  260.21

• Precautions :

  H315, H319, H335

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Non-cleavable Linker

• CAS Number :

  [53053-08-0]