N3-Ph-NHS ester

• Description:

  N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC:

  12352203

• Hazard Statement:

  H315, H319, H335

• Target:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/n3-ph-nhs-ester.html

• Purity:

  99.88

• Solubility:

  DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (ON1C (CCC1=O) =O) C2=CC=C (N=[N+]=[N-]) C=C2

• Molecular Formula:

  C11H8N4O4

• Molecular Weight:

  260.21

• Precautions:

  H315, H319, H335

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Non-cleavable Linker

• CAS Number:

  53053-08-0