Jedi2

• Description :

  Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770 μM[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H317, H319

• Target :

  Piezo Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/jedi2.html

• Concentration :

  10mM

• Purity :

  99.93

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=C(C)OC(C2=CC=CS2)=C1)O

• Molecular Formula :

  C10H8O3S

• Molecular Weight :

  208.23

• Precautions :

  H302, H315, H317, H319

• References & Citations :

  [1]Yanfeng Wang, et al. A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat Commun. 2018 Apr 3;9 (1) :1300.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [651005-90-2]