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4-Formylcolchicine

CAT: 0804-HY-147348-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147348-01Size:5 mg
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Description
4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 μM for A549, HT-29, HCT116 cells, respectively[1][2].
CAS Number
2730-82-7
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-formylcolchicine.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C2C(C([C@H](CCC2=C(C(OC)=C1OC)C=O)NC(C)=O)=C3)=CC=C(OC)C3=O
Molecular Formula
C23H25NO7
Molecular Weight
427.45
References & Citations
[1]Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2 (5) :348-52.|[2]Formylcolchicine bound to lactosaminated serum albumin is a more active antifibrotic agent than free colchicine
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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