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D44

CAT: 0804-HY-W046346Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W046346Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D44 is a Plasmodium FKBP35 inhibitor that selectively inhibits the FKBD35 PPIase activity, with PPIase IC50 values of 132 nM and 125 nM for Plasmodium falciparum and Plasmodium vivax, respectively. D44 exhibits antiplasmodium activity and can be used in research related to infectious diseases[1][2].
CAS Number
826998-10-1
UNSPSC
12352005
Target
FKBP; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/d44.html
Smiles
O=C(CSC1=NC2=CC=CN=C2N1)NC3=CC=CC=C3CC
Molecular Formula
C16H16N4OS
Molecular Weight
312.39
References & Citations
[1]Atack TC, et al. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. ACS Med Chem Lett. 2020 Sep 1;11 (11) :2131-2138. |[2]Harikishore A, et al. Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent[J]. Scientific reports, 2013, 3 (1) : 2501.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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