Rehmannioside A

CAT: 0804-HY-N0911-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0911-01Size:5 mg
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Description
Rehmannioside A is a compound that can be isolated from Rehmanniae radix. Rehmannioside A is an inhibitor of CYP3A4, 2C9 and 2D6, with IC50 values of 10.08, 12.62 and 16.43 μM, respectively. Rehmannioside A has anti-inflammatory, antioxidant, anti-apoptosis, anti-ferroptosis, cognitive improvement and neuroprotective activities. Rehmannioside A can be used for the research of nervous system and inflammation-related diseases[1][2][3][4].
CAS Number
[81720-05-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bcl-2 Family; COX; Cytochrome P450; Ferroptosis; Lactate Dehydrogenase; MEK; NF-κB; NO Synthase; p38 MAPK; PARP; PERK; Reactive Oxygen Species (ROS) ; SOD
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Rehmannioside-A.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
OC[C@@]1([C@]([C@@H]2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO[C@H]([C@@H]([C@H]4O)O)O[C@@H]([C@@H]4O)CO)([H])[C@](C=CO2)([H])[C@@H]5O)[C@@]5([H])O1
Molecular Formula
C21H32O15
Molecular Weight
524.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Xiao S, et al. Rea regulates microglial polarization and attenuates neuronal apoptosis via inhibition of the NF-κB and MAPK signalings for spinal cord injury repair. J Cell Mol Med. 2021 Feb;25 (3) :1371-1382.|[2]Huai L, et al. Rehmannioside A protects against high glucose-induced apoptosis and oxidative stress of renal tubular epithelial cells by inhibiting the MAPK pathway. Tropical Journal of Pharmaceutical Research, 2021, 20 (8) : 1553-1558.|[3]Wang C, et al. Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro. Xenobiotica. 2024 Apr;54 (4) :195-200.|[4]Fu C, et al. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia. J Ethnopharmacol. 2022 May 10;289:115021.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bcl-2; COX-2; CYP2; CYP3; iNOS

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