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(R) -9b

CAT: 0804-HY-113787-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113787-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -9b is a potent inhibitor of ACK1 tyrosine kinase (IC50=56 nM) with anticancer activity. (R) -9b exhibits selectivity for ACK1 but has inhibitory effects on JAK family kinases JAK2 and Tyk2. (R) -9b can be used in the study of hormone-regulated cancers such as prostate and breast cancer[1].
CAS Number
1655527-68-6
UNSPSC
12352005
Target
Ack1; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-9b.html
Purity
99.51
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC[C@@H]4OCCC4)=N3)C=C2)CC1
Molecular Formula
C20H27ClN6O
Molecular Weight
402.92
References & Citations
[1]Lawrence H R, et al. Development of novel ACK1/TNK2 inhibitors using a fragment-based approach[J]. Journal of medicinal chemistry, 2015, 58 (6) : 2746-2763.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; Tyk2

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