Loganic acid (Standard)

• Description:

  Loganic acid (Standard) is the analytical standard of Loganic acid. This product is intended for research and analytical applications. Loganic acid is an iridoid isolated from cornelian cherry fruits. Loganic acid inhibits NF-κB signaling pathway, activates Nrf2 signaling pathway, exhibits anti-inflammatory activity. Loganic acid can modulate diet-induced atherosclerosis and redox status. Loganic acid has strong free radical scavenging activity and remarkable cyto-protective effect against heavy metal mediated toxicity. Loganic acid is orally active[1][2][3][4].

• UNSPSC:

  12352005

• Target:

  Keap1-Nrf2; NF-κB; Phosphatase; Reactive Oxygen Species (ROS) ; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/loganic-acid-standard.html

• Smiles:

  O[C@H] ([C@@H] (O) [C@@H]1O) [C@] (O[C@@H]1CO) ([H]) O[C@H]2[C@@] ([C@H]3C) ([H]) [C@@] (C[C@@H]3O) ([H]) C (C (O) =O) =CO2

• Molecular Formula:

  C16H24O10

• Molecular Weight:

  376.36

• References & Citations:

  [1]Sozański T, et al. Loganic acid and anthocyanins from cornelian cherry (Cornus mas L.) fruits modulate diet-induced atherosclerosis and redox status in rabbits. Adv Clin Exp Med. 2018 Nov;27 (11) :1505-1513.|[2]Abirami A, et al. Antioxidant and cytoprotective properties of loganic acid isolated from seeds of Strychnos potatorum L. against heavy metal induced toxicity in PBMC model. Drug Chem Toxicol. 2019 Oct 23:1-11.|[3]Park E, et al., Osteoprotective Effects of Loganic Acid on Osteoblastic and Osteoclastic Cells and Osteoporosis-Induced Mice. Int J Mol Sci. 2020 Dec 28;22 (1) :233. |[4]Prakash AN, et al. Loganic acid protects against ulcerative colitis by inhibiting TLR4/NF-κB mediated inflammation and activating the SIRT1/Nrf2 anti-oxidant responses in-vitro and in-vivo. Int Immunopharmacol. 2023 Sep;122:110585.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  22255-40-9