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Ro4491533

CAT: 0804-HY-118285Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-118285Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.
CAS Number
579482-31-8
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ro4491533.html
Smiles
O=C1NC2=CC(C(F)(F)F)=C(C=C2N=C(C1)C3=CC=CC(C4=CC(C)=NC(C)=C4)=C3)C
Molecular Formula
C24H20F3N3O
Molecular Weight
423.43
References & Citations
[1]Characterization of an mGluR2/3 Negative Allosteric Modulator in Rodent Models of Depression
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T28600-01Ro4491533

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