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Dehydrocurdione

CAT: 0804-HY-N8160Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N8160Size:1 Each
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Description
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO) -1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity[1][2].
CAS Number
38230-32-9
UNSPSC
12352211
Target
Keap1-Nrf2; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dehydrocurdione.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C(CC1=O)/C(C/C(C)=C/CC[C@@H]1C)=O
Molecular Formula
C15H22O2
Molecular Weight
234.33
References & Citations
[1]Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32 (5) :892-897.|[2]Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47 (12) :476-481.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS5788859Dehydrocurdione

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