Products for Research Use Only
RegisterLogin

Dexloxiglumide

CAT: 0804-HY-128878-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-128878-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Dexloxiglumide is an orally active and selective cholecystokinin type A (CCKA) receptor antagonist. Dexloxiglumide is the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8) . Dexloxiglumide exhibits moderate Caco-2 permeability that is polarized, concentration dependent, and pH dependent. Dexloxiglumide increases MRP1-substrate fluorescein uptake. Dexloxiglumide can be studied in research for gastrointestinal diseases and tumors[1][2][3].
CAS Number
119817-90-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholecystokinin Receptor; P-glycoprotein
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/dexloxiglumide.html
Concentration
10mM
Purity
98.25
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](NC(C1=CC=C(Cl)C(Cl)=C1)=O)C(N(CCCOC)CCCCC)=O
Molecular Formula
C21H30Cl2N2O5
Molecular Weight
461.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Scarpignato C, et al. Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo. Aliment Pharmacol Ther. 1996 Jun;10 (3) :411-9.|[2]Maselli MA, et al. CCK1 receptor antagonist, dexloxiglumide: effects on human isolated gallbladder. Potential clinical applications. Minerva Gastroenterol Dietol. 2003 Sep;49 (3) :211-6.|[3]Tolle-Sander, S., et al., (2003) . Characterization of dexloxiglumide in vitro biopharmaceutical properties and active transport. Journal of pharmaceutical sciences, 92 (10), 1968–1980.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CCKAR

Alternative Products

CatalogName
BA5276-5.1Dexloxiglumide
A18541-100Dexloxiglumide 100mg
A18541-25Dexloxiglumide 25mg
A18541-2Dexloxiglumide 2mg
A18541-5Dexloxiglumide 5mg
A18541-50Dexloxiglumide 50mg
A18541-10Dexloxiglumide 10mg

Popular Products