Meso-tetraphenylchlorin

Meso-tetraphenylchlorin

• CAS Number: 2669-65-0
• UNSPSC Description: Meso-tetraphenylchlorin (TPCS2a) is a photosensitizer with poor water solubility, which limits its use in the blood circulation. However, TPCS2a@NPs nanoparticles can be prepared based on polylactic-co-polyethylene glycol acid (PLGA) polymer core loaded with TPCS2. Such nanoparticles can be coated with mesenchymal stem cell-derived plasma membranes (mMSCs) to form mMSC-TPCS2a@NPs, which prolongs blood circulation time and improves tumor targeting ability. Compared with uncoated TPCS2a@NPs, mMSC-TPCS2a@NPs can reduce macrophage uptake by 54% to 70% under different conditions. Both nanoparticle forms are effectively accumulated in MCF7 and MDA-MB-231 breast cancer cells, while uptake in normal breast epithelial cells MCF10A is significantly lower[1].
• Target Antigen: Photosensitizer
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/meso-tetraphenylchlorin.html
• Smiles: C1(/C(C(N2)=CC=C2/C(C3=CC=CC=C3)=C4CCC5=N\4)=C6C=CC(/C(C7=CC=CC=C7)=C(N/8)\CCC8=C5\C9=CC=CC=C9)=N/6)=CC=CC=C1
• Molecular Weight: 618.77
• References & Citations: [1]Mesenchymal Stem Cell Membrane-Coated TPCS2a-Loaded Nanoparticles for Breast Cancer Photodynamic Therapy
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported