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Dasolampanel

CAT: 0804-HY-19465-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19465-01Size:1 mg
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Description
Dasolampanel is a kainate receptor antagonist that helps regulate the excitability of the nervous system by blocking kainate receptors and reducing glutamate-mediated excitatory transmission. Dasolampanel can be used in the study of diseases such as overexcitement and sleep disorders[1].
CAS Number
503294-13-1
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dasolampanel.html
Smiles
O=C([C@H]1NC[C@]2([H])CC[C@H](OC3=CC=CC(Cl)=C3C4=NN=CN4)C[C@]2([H])C1)O
Molecular Formula
C18H21ClN4O3
Molecular Weight
376.84
References & Citations
[1]LiPing Wang, et al. Antagonist composition and application thereof in preparation of drug for treatment of sleep disorders with co-morbid psychiatric disorders. WO2023125112A1.2022-12-19
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dasolampanel

Dasolampanel is a member of tetrazoles.

CAS Number503294-13-1
PubChem CID51049972
IUPAC Name(3S,4aS,6S,8aR)-6-[3-chloro-2-(2H-tetrazol-5-yl)phenoxy]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
Molecular FormulaC17H20ClN5O3
Molecular Weight377.8
XLogP0.2
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity513
SMILES
C1C[C@H]2CN[C@@H](C[C@H]2C[C@H]1OC3=C(C(=CC=C3)Cl)C4=NNN=N4)C(=O)O
InChI
InChI=1S/C17H20ClN5O3/c18-12-2-1-3-14(15(12)16-20-22-23-21-16)26-11-5-4-9-8-19-13(17(24)25)7-10(9)6-11/h1-3,9-11,13,19H,4-8H2,(H,24,25)(H,20,21,22,23)/t9-,10+,11-,13-/m0/s1
InChIKey
LAKQPSQCICNZII-NOHGZBONSA-N
Chemical Structure
2D Structure
2D structure of Dasolampanel
CAS: 503294-13-1
CID: 51049972
Formula: C17H20ClN5O3
MW: 377.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight377.8
XLogP30.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass377.1254672
Monoisotopic Mass377.1254672
Topological Polar Surface Area113 Ų
Heavy Atom Count26
Formal Charge0
Complexity513
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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