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Olanzapine

CAT: 0804-HY-14541-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-14541-01Size:50 mg
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Description
Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM) . Olanzapine is an atypical antipsychotic[1][2].
CAS Number
[132539-06-1]
Product Name Alternative
LY170053
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Adrenergic Receptor; Apoptosis; Autophagy; Dopamine Receptor; mAChR; Mitophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Olanzapine.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
CC1=CC(C(N2CCN(C)CC2)=N3)=C(S1)NC4=C3C=CC=C4
Molecular Formula
C17H20N4S
Molecular Weight
312.44
Precautions
H302, H315, H319, H335
References & Citations
[1]APPROVED AGREED-UPON LABELING.|[2]Olanzapine for Injection, powder, for solution for intramuscular use.|[3]Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10 (12) :2362-78.|[4]Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect. J Neurooncol. 2015 Mar;122 (1) :21-33.|[5]Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl) . 2006 Jul;186 (4) :561-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT2 Receptor;5-HT6 Receptor; Dopamine Receptor; lactoferrin; mLAG-3; MUC2; α-1 microglobulin

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