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2'-Aminoacetophenone

CAT: 0804-HY-I0501-01Size: 10 gDry Ice: NoHazardous: No
CAT#:0804-HY-I0501-01Size:10 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle[1][2][4].
CAS Number
[551-93-9]
Product Name Alternative
O-aminoacetophenone
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Atg8/LC3; Autophagy; Bacterial; p62
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-aminoacetophenone.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC=CC=C1N)=O
Molecular Formula
C8H9NO
Molecular Weight
135.17
Precautions
H315, H319, H335
References & Citations
[1]Chakraborty A, et al. Quorum-Sensing Signaling Molecule 2-Aminoacetophenone Mediates the Persistence of Pseudomonas aeruginosa in Macrophages by Interference with Autophagy through Epigenetic Regulation of Lipid Biosynthesis. mBio. 2023 Apr 25;14 (2) :e0015923.|[2]Scott-Thomas AJ, et al. 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung. BMC Pulm Med. 2010 Nov 7;10:56.|[3]Kapsetaki SE, et al. The bacterial metabolite 2-aminoacetophenone promotes association of pathogenic bacteria with flies. Nat Commun. 2014 Jul 21;5:4401. |[4]Bandyopadhaya A, et al. Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle. Int J Mol Med. 2016 Apr;37 (4) :867-78.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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