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SWE101

CAT: 0804-HY-126326-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-126326-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH) -P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH[1].
CAS Number
2376322-12-0
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/swe101.html
Concentration
10mM
Purity
98.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CCCC1=NC(C2=CC=C(Cl)C(Cl)=C2)=C(C3=CC=CC=C3)O1
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
References & Citations
[1]Kramer JS, et al. Discovery of first in vivo active inhibitors of soluble epoxide hydrolase (sEH) phosphatase domain. J Med Chem. 2019 Aug 22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-[4-(3,4-Dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]butanoic acid
CAS Number2376322-12-0
PubChem CID139035063
IUPAC Name4-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]butanoic acid
Molecular FormulaC19H15Cl2NO3
Molecular Weight376.2
XLogP5.1
Topological Polar Surface Area63.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity444
SMILES
C1=CC=C(C=C1)C2=C(N=C(O2)CCCC(=O)O)C3=CC(=C(C=C3)Cl)Cl
InChI
InChI=1S/C19H15Cl2NO3/c20-14-10-9-13(11-15(14)21)18-19(12-5-2-1-3-6-12)25-16(22-18)7-4-8-17(23)24/h1-3,5-6,9-11H,4,7-8H2,(H,23,24)
InChIKey
UIADWSXPNFQQCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[4-(3,4-Dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]butanoic acid
CAS: 2376322-12-0
CID: 139035063
Formula: C19H15Cl2NO3
MW: 376.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.2
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass375.0428987
Monoisotopic Mass375.0428987
Topological Polar Surface Area63.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity444
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA7685-5.1SWE101

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