CK0492B

CAT: 0804-HY-123479Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-123479Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CK0492B is a novel biaminourea antibiotic that has antiplaque properties in vitro and has shown efficacy in an experimental mouse dental disease model. A 12-week study in beagles compared its efficacy in reducing plaque and gingivitis, staining potential, and safety. Dogs were selected as the study subjects because the onset and progression of canine periodontal disease are similar to humans. Chlorhexidine acetate was selected as a positive control for plaque and gingivitis reduction and staining because it is effective in both humans and dogs.

CAS Number

64169-11-5

UNSPSC

12352005

Target

Antibiotic

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ck0492b.html

Smiles

O=C(NC12CC3CC(C2)CC(C1)C3)NC(NCCCN4CCN(CCCNC(NC(NC56CC7CC(C6)CC(C5)C7)=O)=N)CC4)=N.O=S(O)(C)=O.O=S(O)(C)=O

Molecular Formula

C36H66N10O8S2

Molecular Weight

831.10

References & Citations

[1]Basic Biological Sciences: Effects of Chlorhexidine and Four Antimicrobial Compounds on Plaque, Gingivitis, and Staining in Beagle Dogs

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CK0492B

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