VBIT-4

CAT: 0804-HY-129122-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-129122-01Size:5 mg
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Description
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].
CAS Number
[2086257-77-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
VDAC
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/vbit-4.html
Purity
99.46
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=C(NC1=CC=C(Cl)C=C1)CC(CO)N2CCN(C3=CC=C(OC(F)(F)F)C=C3)CC2
Molecular Formula
C21H23ClF3N3O3
Molecular Weight
457.87
Precautions
H315, H319, H335
References & Citations
[1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291 (48) :24986-25003.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VDAC1

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