VBIT-4

• UNSPSC Description:

  VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

• Target Antigen:

  VDAC

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/vbit-4.html

• Purity:

  99.46

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;adjust pH to 3 with HCl)

• Smiles:

  O=C(NC1=CC=C(Cl)C=C1)CC(CO)N2CCN(C3=CC=C(OC(F)(F)F)C=C3)CC2

• Molecular Weight:

  457.87

• References & Citations:

  [1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  2086257-77-2