VBIT-4

• Description :

  VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  VDAC

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/vbit-4.html

• Purity :

  99.46

• Solubility :

  DMSO : 125 mg/mL (ultrasonic) |H2O : 1 mg/mL (ultrasonic; adjust pH to 3 with HCl)

• Smiles :

  O=C(NC1=CC=C(Cl)C=C1)CC(CO)N2CCN(C3=CC=C(OC(F)(F)F)C=C3)CC2

• Molecular Formula :

  C21H23ClF3N3O3

• Molecular Weight :

  457.87

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291 (48) :24986-25003.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  VDAC1

• CAS Number :

  [2086257-77-2]