Segetalin B

CAT: 0804-HY-107245-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107245-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) [1][2][3][4].
CAS Number
[164991-89-3]
UNSPSC
12352209
Target
Estrogen Receptor/ERR; RUNX; Sirtuin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/segetalin-b.html
Purity
99.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N1)=O)C)=O)C(C)C)=O)=O)C)[C@@H]1CC2=CNC3=CC=CC=C23
Molecular Formula
C24H32N6O5
Molecular Weight
484.55
References & Citations
[1]HiroshiMorita, et al. Segetalins B, C and D, three new cyclic peptides from Vaccaria segetalis. Tetrahedron Volume 51, Issue 21, 22 May 1995, Pages 6003-6014.|[2]PascalSonnet, et al. First synthesis of segetalins B and G: two cyclopentapeptides with estrogen-like activity. Tetrahedron Letters. Volume 44, Issue 16, 14 April 2003, Pages 3293-3296|[3]DONG H, et al. HPLC simultaneous determination of segetalin A and segetalin B in Vaccariae Semen[J]. Chinese Journal of Pharmaceutical Analysis, 2012, 32 (5) : 793-796.|[4]Lan X, et al. SIRT1/Notch1 signal axis involves in the promoting effect of Segetalin B on bone formation. Drug Dev Res. 2022 Dec;83 (8) :1845-1857.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
RUNX2; SIRT1

Related Products

CatalogName
HY-107246-01Segetalin A
HY-N13127Segetalin C
HY-N11436-01Aconicarchamine B
HY-N7688-01Regaloside B
HY-N7552-01Isodaphnoretin B
HY-N3576-01Henriol B
HY-N4184-01Licoflavone B
HY-N8167-01Plantanone B
HY-D0259-01Erythrosine B
HY-N2365-01Macamide B

Alternative Products

CatalogName
AB1490Segetalin A
MBS5759727Segetalin B
TN8092-01Segetalin C
M21737-01Segetalin A trifluoroacetic acid salt

Popular Products