Pyrimidine

• Description :

  Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite. Pyrimidine derivatives can be used in pancreatic cancer, triple-negative breast cancer, colon carcinoma and neuron research[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H226

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pyrimidine.html

• Purity :

  99.99

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C1=NC=CC=N1

• Molecular Formula :

  C4H4N2

• Molecular Weight :

  80.09

• Precautions :

  H226

• References & Citations :

  [1]Halbrook CJ, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metab. 2019 Jun 4;29 (6) :1390-1399.e6.|[2]Inoue K. Microglial activation by purines and pyrimidines. Glia. 2002 Nov;40 (2) :156-163.|[3]Taglieri L, et al. Discovery of a pyrimidine compound endowed with antitumor activity. Invest New Drugs. 2020 Feb;38 (1) :39-49.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 2

• CAS Number :

  [289-95-2]