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Halicin

CAT: 0804-HY-107597-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107597-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Halicin (SU3327) is a potent, selective and substrate-competitive JNK inhibitor with an IC50 of 0.7 μM. Halicin also inhibits protein-protein interactions between JNK and JNK Interacting Protein (JIP) with an IC50 of 239 nM. Halicin shows less active against p38α and Akt kinase[1][2].
CAS Number
40045-50-9
Product Name Alternative
SU3327
UNSPSC
12352005
Hazard Statement
H315, H319
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/halicin.html
Concentration
10mM
Purity
98.92
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
NC1=NN=C(S1)SC2=NC=C([N+]([O-])=O)S2
Molecular Formula
C5H3N5O2S3
Molecular Weight
261.30
Precautions
H315, H319
References & Citations
[1]De SK, et al. Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase. J Med Chem. 2009 Apr 9;52 (7) :1943-52.|[2]Augustine C, et al. Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro. Neuroscience. 2014 Aug 22;274:1-10.|[3]Serizawa F, et al. Pretreatment of human cerebrovascular endothelial cells with CO-releasing molecule-3 interferes with JNK/AP-1 signaling and suppresses LPS-induced proadhesive phenotype. Microcirculation. 2015 Jan;22 (1) :28-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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