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TCPOBOP

CAT: 0804-HY-103243-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103243-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
CAS Number
76150-91-9
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tcpobop.html
Purity
99.70
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
Molecular Formula
C16H8Cl4N2O2
Molecular Weight
402.06
Precautions
H315, H319, H320
References & Citations
[1]Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69 (4) :1702-1718.|[2]Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44 (1) :252-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2

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B6644-50TCPOBOP
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A18376-200TCPOBOP 200mg
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