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Vibecotamab

CAT: 0804-HY-P99521-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99521-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/ (scFv-heavy-lambda) -h-CH2-CH3[1][2][3].
CAS Number
2138442-13-2
Product Name Alternative
XmAb14045
UNSPSC
12352203
Target
CD3
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vibecotamab.html
Purity
99.34
Solubility
10 mM in DMSO
Smiles
[Vibecotamab]
Molecular Weight
(126.15 kDa)
References & Citations
[1]FarhadRavandiMBBS, et al. Complete Responses in Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients on a Weekly Dosing Schedule of Vibecotamab (XmAb14045), a CD123 x CD3 T Cell-Engaging Bispecific Antibody; Initial Results of a Phase 1 Study. Blood, Volume 136, Supplement 1, 5 November 2020, Pages 4-5|[2]Nicholas James Short et al., Meeting Abstract: 2023 ASCO Annual Meeting I, Journal of Clinical Oncology, Volume 41, Number 16|[3]Seung Y. Chu, et al., (2014) Immunotherapy with Long-Lived Anti-CD123 x Anti-CD3 Bispecific Antibodies Stimulates Potent T Cell-Mediated Killing of Human AML Cell Lines and of CD123+ Cells in Monkeys: A Potential Therapy for Acute Myelogenous Leukemia, Blood, Volume 124, Issue 21, Page 2316, ISSN 0006-4971.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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