β-Hydroxyisovalerylshikonin

CAT: 0804-HY-N4201-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N4201-01Size:1 mg
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Description
Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].
CAS Number
[7415-78-3]
UNSPSC
12352005
Hazard Statement
H301, H315, H317, H319
Target
EGFR; Src
Type
Natural Products
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/beta-hydroxyisovalerylshikonin.html
Purity
99.83
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)(O)CC(O[C@@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)=O
Molecular Formula
C21H24O7
Molecular Weight
388.41
Precautions
H301, H315, H317, H319
References & Citations
[1]Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93 (8) :944-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS5760183Beta-Hydroxyisovalerylshikonin

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