β-Hydroxyisovalerylshikonin

• Description:

  Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H315, H317, H319

• Target:

  EGFR; Src

• Type:

  Natural Products

• Related Pathways:

  JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/beta-hydroxyisovalerylshikonin.html

• Purity:

  99.83

• Solubility:

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CC (C) (O) CC (O[C@@H] (C (C1=O) =CC (C2=C1C (O) =CC=C2O) =O) C/C=C (C) \C) =O

• Molecular Formula:

  C21H24O7

• Molecular Weight:

  388.41

• Precautions:

  H301, H315, H317, H319

• References & Citations:

  [1]Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93 (8) :944-51.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  7415-78-3