Neratinib (Standard)

• UNSPSC Description:

  Neratinib (Standard) is the analytical standard of Neratinib. This product is intended for research and analytical applications. Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1].

• Target Antigen:

  EGFR

• Type:

  Reference Standards

• Related Pathways:

  JAK/STAT Signaling;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/neratinib-standard.html

• Smiles:

  ClC1=C(OCC2=NC=CC=C2)C=CC(NC3=C(C#N)C=NC4=CC(OCC)=C(NC(/C=C/CN(C)C)=O)C=C43)=C1

• Molecular Weight:

  557.04

• References & Citations:

  [1]Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64(11), 3958-3965.

• Shipping Conditions:

  Room temperature

• CAS Number:

  698387-09-6