Neratinib (Standard)

CAT: 0804-HY-32721R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-32721R-01Size:5 mg
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Description
Neratinib (Standard) is the analytical standard of Neratinib. This product is intended for research and analytical applications. Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC50s of 59 nM and 92 nM, respectively[1].
CAS Number
[698387-09-6]
Product Name Alternative
HKI-272 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; Reference Standards
Type
Reference Standards
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/neratinib-standard.html
Purity
99.25
Smiles
ClC1=C(OCC2=NC=CC=C2)C=CC(NC3=C(C#N)C=NC4=CC(OCC)=C(NC(/C=C/CN(C)C)=O)C=C43)=C1
Molecular Formula
C30H29ClN6O3
Molecular Weight
557.04
Precautions
H302, H315, H319, H335
References & Citations
[1]Rabindran SK, et al. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res, 2004, 64 (11), 3958-3965.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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