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D-Isoleucine

CAT: 0804-HY-I1070-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-I1070-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM) . D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia) . D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].
CAS Number
319-78-8
Product Name Alternative
(R) -Isoleucine
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
ASCT
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/d-isoleucine.html
Purity
99.83
Solubility
H2O : 5.56 mg/mL (ultrasonic)
Smiles
CC[C@@H](C)[C@@H](N)C(O)=O
Molecular Formula
C6H13NO2
Molecular Weight
131.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33 (8) :3533-44.|[2]Dörries K, et al. Metabolic footprint analysis uncovers strain specific overflow metabolism and D-isoleucine production of Staphylococcus aureus COL and HG001. PLoS One. 2013 Dec 3;8 (12) :e81500.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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