(E)-[6]-Dehydroparadol

• UNSPSC Description:

  (E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E)-[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2].

• Target Antigen:

  Apoptosis; Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/_E_-[6]-Dehydroparadol.html

• Purity:

  95.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCC(/C=C/C1=CC=C(O)C(OC)=C1)=O

• Molecular Weight:

  276.37

• References & Citations:

  [1]Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57(5):865-76.|[2]Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  878006-06-5