(E) -[6]-Dehydroparadol

• Description :

  (E) -[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol (HY-14616), is a potent Nrf2 activator. (E) -[6]-Dehydroparadol can inhibit the growth and induce the apoptosis of human cancer cells[1][2].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; NF-κB

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/_E_-[6]-Dehydroparadol.html

• Purity :

  95.0

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CCCCCCCC(/C=C/C1=CC=C(O)C(OC)=C1)=O

• Molecular Formula :

  C17H24O3

• Molecular Weight :

  276.37

• References & Citations :

  [1]Chen H, et, al. Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human. Mol Nutr Food Res. 2013 May;57 (5) :865-76.|[2]Zhu Y, et, al. Synthesis, evaluation, and metabolism of novel [6]-shogaol derivatives as potent Nrf2 activators. Free Radic Biol Med. 2016 Jun;95:243-54.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [878006-06-5]